Corona vaccination: What is the long-term influence of the vaccine?

Side effects of the corona vaccines such as severe sinus vein thrombosis or possible heart muscle inflammation repeatedly cause media uproar. In most cases, these are acute vaccination reactions, which can be treated medically. There are no long-term studies on the corona vaccination so far. A study that has not yet been scientifically verified also caused a stir. Scientists examined the impact of the BioNTech/Pfizer vaccine.

Vaccination critics see their previous claims and theses on long-term long-term effects of the vaccine supported by the study by the Dutch and German researchers at the University of Nijmegen. However, it must be emphasized that the study has only been previously published and has therefore not yet been scientifically reviewed.

mRNA vaccines could affect the immune system

As part of the study, scientists examined the blood serum of healthy vaccinees before and after the vaccination. The focus here was on cytokines, which activate certain immune cells and support the  immune system  in the event of infections and  inflammation  . In order to analyze the immune response of the vaccinees,  blood samples were  taken and confronted with various pathogens.

A lower immune response to viruses and bacteria was seen in some of the subjects, but the immune response to  fungi  was enhanced.

The study has provided the following findings so far, but due to the small number of subjects, it is advisable to carry out the study with larger groups of people:

  • The corona vaccination with the  mRNA vaccine  from BioNTech/Pfizer protects against a severe course with an effectiveness of up to 95 percent.
  • Vaccination could, however, affect the innate immune system.
  • While the immune response to viruses and bacteria is weaker, the innate immune response to fungi is enhanced.

Influence on the innate immune response

According to the scientists, the corona vaccination could lead to a “reprogramming of the immune system”. The innate immune system would be particularly affected.

The innate immune system, also known as the non-specific immune system, reacts first to pathogens of all kinds. The reaction always occurs in the same way.

The acquired immune system, on the other hand, specifically targets pathogens if the innate immune system was unable to destroy them. The prerequisite is that the immune system has already been in contact with the pathogen and has built up the necessary protection. This can take place both in the course of a vaccination and after an infection has already been overcome. The specific immune response reacts in a targeted manner and as a result is usually very effective.

Immune system not overridden after mRNA vaccination

If the results should be confirmed, they will provide an important finding, but according to the current state of knowledge, this will not have any serious consequences. The changes regarding some pathogens are measurable, but only very small. In addition, the innate immune system makes up only a very small part of the complex immune system.

In addition to the  corona vaccines  , other vaccines, for example against measles, mumps and rubella, also have an impact on the immune system. However, since the benefit of vaccination is greater than the risk of a possible change, doctors recommend vaccination. Studies also show that a change in the innate immune system often works in favor of the more effective acquired immune system.

Damage from infections greater

Even severe infections can lead to long-term changes or weakening of the immune system, such as  measles  or  COVID-19 .

Overall, the researchers’ findings provide important information regarding the corona vaccination. However, the advantages of vaccination outweigh the disadvantages.

Long-term studies after corona vaccination: Mertens reacts to Kimmich

After soccer player Joshua Kimmich expressed his concerns about the corona vaccination last Saturday due to a lack of long-term studies, Thomas Mertens, head of the Standing Vaccination Committee (STIKO), reacted. In an interview with the dpa, Mertens emphasized that in the case of the new corona vaccines there could not yet be any ten-year observational studies. However, the accompanying approval studies are examining the possibility of serious side effects. In addition, there would also be no long-term studies for newly approved drugs at this point in time. The general knowledge of science is that side effects occurring late with vaccinations do not occur or represent a very rare rarity of individual vaccines.

Many skeptics of the new types of vaccine are waiting for the first dead vaccine against the  coronavirus . But despite successful studies, approval can be expected in 2022 at the earliest. Manufacturers of the inactivated vaccine therefore advise using the previous vaccination offers. Inactivated vaccines could then serve as possible and effective boosters.


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