Moderna – Booster vaccination can protect against Omicron

The omicron variant of SARS-CoV-2 is already on the rise in Europe. The mutation is considered to be particularly contagious and can also bypass vaccination protection. Initial studies with corona vaccines that have already been approved hardly show any effectiveness against omicron, but a booster vaccination could help.

Omikron can escape the vaccination protection of the vaccines from  AstraZenecaModerna  and BioNTech/Pfizer. The booster vaccination is all the more important: After it was already known that a booster vaccination at BionTech/Pfizer could increase protection against omicron, this is also possible with the vaccine from Moderna according to new findings.

Moderna Vaccination: That’s how important the booster against Omicron is

In a first study, experts compared the blood serum of all participants. One group received the second vaccination only four weeks earlier, while another group received the booster two weeks earlier.

Overall, the neutralizing effect of the antibodies against

  • D614G, which corresponds in structure to the wild type of  SARS-CoV-2  ,
  • the beta variant that has already appeared in Africa
  • and the omicron mutation


After the primary immunization, the neutralizing effect of the antibodies against Omicron was 49 to 84 times weaker than against the wild type of SARS-CoV-2 and 9.2 to 13.6 times weaker than against the beta variant.

The consequence: a basic immunization with Moderna could not provide sufficient protection against an infection with Omikron. The risk of breakthrough infection is higher than with other virus variants.

However, the booster vaccination gives reason for confidence: the effect of the vaccine was only 4.2 to 6.5 times weaker after the booster than against the wild type. Experts therefore suspect that a booster vaccination can lead to a significantly milder course of the disease. How an infection with the virus behaves in vaccinated people is not yet sufficiently known and will be researched further in the coming weeks.


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