Myocarditis after corona vaccination: What role do lipid nanoparticles play?

The risk of heart muscle inflammation (myocarditis) can increase after corona vaccination with the mRNA vaccines BioNTech/Pfizer and Moderna, especially in young people. However, the cause of the inflammation of the heart muscle has not yet been clarified. Greek experts now offer an interesting food for thought.

Due to the increased risk of   heart  muscle inflammation  ,  Moderna ‘s corona vaccine  is only recommended for people over 30 years of age. Why heart muscle inflammation occurs particularly in younger people has not yet been sufficiently clarified.

Myocardial Inflammation: Are Lipid Nanoparticles in mRNA Vaccines Responsible?

In inflammation of the heart muscle, also known as myocarditis, viruses or bacteria infect the muscle tissue of the heart. Your own defense cells can also attack the heart muscle and lead to inflammation if the immune system is disturbed   .

Myocarditis can occur especially in young men and women after  mRNA vaccination  . Researchers are already looking for the cause. Greek experts are now giving various food for thought.

In addition to an overreaction of the immune system or hormonal influences, components of the mRNA vaccine could also be responsible for inflammation of the heart muscle after the mNRA vaccination.

In particular, lipid nanoparticles (LNP), a type of fat cells that serve as a means of transport for drugs, are moving into the focus of research. Since heart muscle inflammation occurs just after vaccination with an mRNA vaccine, the lipid nanoparticles used there could play an important role in its development. This is because other types of vaccine do not contain these particles.

The nanoparticles are also used in other areas as a means of transport for medicines and other ingredients, for example in chemotherapy and flu vaccines. So far, however, no increased myocarditis risk has been determined in connection with these substances.

This can be explained by the high vaccination rate worldwide and intensive monitoring of the side effects of corona vaccines. In this way, inflammation of the heart muscle and other consequences could be recognized quickly and linked to the vaccination.

Another reason for the previously undiscovered side effects of LNPs in other drugs could be that the drugs have only rarely been used in the affected age group (under 30 years). In these cases, too, LNPs could trigger an immune reaction or infect myocardial cells unnoticed – but nothing is known about this so far.

The cause of the disease should be further investigated

Since the mRNA vaccines are highly likely to prevent severe courses of  COVID-19  and myocarditis can also occur more frequently after a corona infection, vaccination is still urgently recommended.

Especially in the context of the booster vaccinations that are running worldwide, the researchers point out that the cause should continue to be investigated in order to be able to prevent possible inflammation of the heart muscle in the future.

Most heart muscle inflammations are mild and those affected recover on their own. However, as a precaution, it is recommended to refrain from exercising on the day of the vaccination and for one or two days afterwards. If symptoms are possible, medical advice should be sought.


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