Novaminsulfone (Novalgin®) – dangerous side effects

The most common side effects of Novaminsulfon include  nausea  and vomiting and a slight red discoloration of the urine. In addition, circulatory fluctuations can also occur. Very rarely, skin changes, confusion and impaired consciousness may also occur.

However, if Novaminsulfon is taken over the long term, the painkiller can also cause organ damage, especially to the kidneys.

Side effects of Novalgin ®

Occasional  side effects of Novalgin ®  are a purple to red, sometimes blistering skin rash and a drop in blood pressure. The risk of a drop in blood pressure may be increased if you have an extremely high fever.

Typical signs of a drop in blood pressure are:

  • Revise
  • paleness
  • Tremble
  • nausea
  • dizziness and  fainting

Rare side effects of Novalgin ®

The rare side effects primarily include hypersensitivity reactions. These can also occur after repeated problem-free use and be life-threatening.

Signs of a mild hypersensitivity reaction are:

  • burning eyes
  • Cough, sneeze, runny nose
  • a tightness in the chest
  • redness of the skin (especially on the face)
  • hives
  • nausea and abdominal cramps
  • a burning,  itching  and feeling of heat on and under the  tongue  and especially on the palms and soles

Under certain circumstances, mild reactions can progress to a severe hypersensitivity reaction and cause severe hives, swelling, spasmodic constriction of the airways,  cardiac arrhythmia , drop in blood pressure and circulatory shock. Another rare side effect of Novalgin ®  is a reduced number of white blood cells.

Very rarely  , an asthma attack, an acute deterioration in kidney function up to and including kidney failure and extensive blistering of the skin (Stevens-Johnson syndrome) can occur.

Novaminsulfon: Beware of allergic reactions

In rare cases, taking Novaminsulfone can lead to a hypersensitivity reaction and subsequent shock. In the worst case, this side effect can have fatal consequences.

In the case of pre-existing conditions such as  bronchial asthma  or hay fever, taking Novaminsulfon can also trigger an attack. This side effect occurs mainly when Novaminsulfon is injected too quickly. A critical drop in blood pressure can then also occur.

Compared to other painkillers, however, it is positive to note that Novaminsulfone is very well  tolerated  by the stomach . In addition, there is no potential for addiction, as there is with opioids, for example.

Agranulocytosis as a serious side effect

In very rare cases, taking Novaminsulfon can damage cell formation in the bone marrow (agranulocytosis). Granulocytes – a subtype of leukocytes – are formed in the bone marrow. Typical symptoms of agranulocytosis are initially fever and  chills . Over time, the inflammation can spread to the entire body and  sepsis  can occur.

If Novaminsulfon is discontinued after the symptoms have appeared and the damage is treated accordingly, the damage is usually reversible. However, if the painkiller continues to be taken, the mortality rate is around ten percent. The risk of agranulocytosis is particularly high when novaminsulfone is administered intravenously.

disagreement about the frequency of side effects

How often this serious side effect actually occurs is controversial among scientists. While some studies assume a probability of around 1:1,000,000, other studies estimate the risk to be significantly higher at 1:1,439.

The different results are probably due, among other things, to a different dose and a different length of time the drug was taken.

Novaminsulfone: Banned in some countries

Due to its dangerous side effects, the administration of Novaminsulfone is not permitted in some countries, such as England, Japan, Denmark, Sweden or the USA.

In Germany, however, the use is permitted. However, Novaminsulfone is usually only used for short-term treatments and only for certain areas of application. For example, the Federal Institute for Drugs and Medical Devices only recommends taking Novaminsulfon to treat severe pain or in situations where other medications do not work.

Patients taking Novaminsulfon should have blood counts taken regularly and contact their doctor directly if they become infected.


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